IL-27 抗体
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北京 101111
Quick Overview for IL-27 抗体 (ABIN2666012)
抗原
See all IL-27 (IL27) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- This product is produced with low endotoxin and is supplied azide free.
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纯化方法
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
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过滤
- 0.2 μm filtered
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内毒素水平
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Endotoxin level is <0.01 EU/μg of the protein (<0.001 ng/μg of the protein) as determined by the LAL test.
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亚型
- IgG2a
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anti-Interleukin 27 (IL27) (AA 177-243) antibody
IL27 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F12 unconjugated
anti-Interleukin 27 (IL27) (C-Term) antibodyIL27 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 1-243) antibodyIL27 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 1-243) antibodyIL27 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (N-Term) antibodyIL27 适用: 人, 小鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 57-87) antibodyIL27 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB3263 unconjugated
anti-Interleukin 27 (IL27) antibodyIL27 适用: 小鼠 WB, ELISA, FACS, MA 宿主: 大鼠 Monoclonal 3H12-F10 unconjugated
anti-Interleukin 27 (IL27) (AA 29-243) antibodyIL27 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 31-46) antibodyIL27 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) antibodyIL27 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal B-G49 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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储存液
- Azide free
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注意事项
- This Ultra-LEAF™ solution contains no preservative, handle under aseptic conditions
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- IL-27 (IL27) (Interleukin 27 (IL27))
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别名
- IL-27 p28
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背景
- IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40-related protein) and p28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naive CD4+ T cells, and promotes Th1 polarization and IFN-γ production in synergy with IL-12. The IL-27-induced Th1 differentiation was mediated by rapid and marked upregulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 exhibits anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation. It also plays a potential therapeutic role in autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rβ2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27.
抗原
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