Thymic Stromal Lymphopoietin 抗体
Quick Overview for Thymic Stromal Lymphopoietin 抗体 (ABIN2665441)
抗原
See all Thymic Stromal Lymphopoietin (TSLP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG1 kappa
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anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibody
TSLP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibodyTSLP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibodyTSLP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D12 unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 101-159) antibodyTSLP 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 29-159) antibodyTSLP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 21-138) antibodyTSLP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 89-138) antibodyTSLP 适用: 人, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) antibodyTSLP 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 75-196) antibodyTSLP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymic Stromal Lymphopoietin (TSLP) (AA 101-130) antibodyTSLP 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Thymic Stromal Lymphopoietin (TSLP)
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别名
- TSLP
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背景
- Thymic Stromal Lymphopoietin (TSLP) is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recent studies revealed that expression of TSLP has a direct link to the pathogenesis of allergic inflammation such as atopic dermatitis and asthma via activating dendritic cells and mast cells which trigger inflammatory Th2 response characterized by high TNF-alpha and little IL-10 production.
抗原
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