RUNX1 抗体
Quick Overview for RUNX1 抗体 (ABIN2665355)
抗原
See all RUNX1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 小鼠, 人
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交叉反应 （详细）
- Human
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG2a kappa
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anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 210-310) antibody
RUNX1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 150-250) antibodyRUNX1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 221-480) antibodyRUNX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) antibodyRUNX1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 210-310) antibodyRUNX1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3A1 unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (pSer304) antibodyRUNX1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 227-255) antibodyRUNX1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 237-337) antibodyRUNX1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6C12A5 unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) antibodyRUNX1 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 5A1 unconjugated
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 200-233), (Middle Region) antibodyRUNX1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
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别名
- RUNX1
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背景
- RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukaemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. RUNX1-deficient mice fail to generate hematopoietic stem cells. RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. Impaired differentiation of megakaryocytes and decreased circulating platelet count was observed in the absence of RUNX1. These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages.
抗原
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