LIF 抗体
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Quick Overview for LIF 抗体 (ABIN2665228)
抗原
See all LIF 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG2a
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anti-Leukemia Inhibitory Factor (LIF) (AA 2-201) antibody
LIF 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 2-201) antibodyLIF 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 72-101) antibodyLIF 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 101-202) antibodyLIF 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 23-202) antibodyLIF 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 72-101) antibodyLIF 适用: 人, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21725 unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 23-202) antibodyLIF 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (C-Term) antibodyLIF 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (C-Term) antibodyLIF 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Leukemia Inhibitory Factor (LIF) (AA 25-203) antibodyLIF 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- LIF (Leukemia Inhibitory Factor (LIF))
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别名
- LIF
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背景
- Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190, and the subunit gp130. The LIF complex receptor signals though STAT3 and JAK kinases. LIF expression has been observed in various tissues including the thymus, lung, and neuronal tissue. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contributes to stem cell self-renewal. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, as well as the induction of neuronal cell differentiation. It also regulates mesenchymal to epithelial conversion during kidney development, and also may have a role in immune tolerance at the maternal-fetal interface. LIF can be upregulated by pro-inflammatory cytokines such as TNF-α and IL-17. Elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis.
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途径
- JAK/STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding
抗原
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