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IRF2 抗体

IRF2 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 13B2A38 unconjugated
产品编号 ABIN2665203
发货至: 中国
  • 抗原 See all IRF2 抗体
    IRF2 (Interferon Regulatory Factor 2 (IRF2))
    适用
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    人, 小鼠
    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This IRF2 antibody is un-conjugated
    应用范围
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    Western Blotting (WB)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    13B2A38
    亚型
    IgG1 kappa
    Top Product
    Discover our top product IRF2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    IRF2 (Interferon Regulatory Factor 2 (IRF2))
    别名
    IRF2 (IRF2 产品)
    别名
    IRF-2 antibody, 9830146E22Rik antibody, AI646973 antibody, Irf-2 antibody, irf2b antibody, zgc:103451 antibody, irf-2 antibody, wu:fc74h04 antibody, zgc:76951 antibody, interferon regulatory factor 2 antibody, interferon regulatory factor 2 L homeolog antibody, interferon regulatory factor 2a antibody, IRF2 antibody, Irf2 antibody, irf2 antibody, irf2.L antibody, irf2a antibody
    背景
    IRF2 is a member of the IRF family of transcription factors, mainly functioning as a transcriptional repressor. It binds to the interferon-sensitive response elements (ISREs) and competes for binding sites with the other IRF transcription factors, such as IRF1 and IRF9. Mice deficient in IRF2 spontaneously develop skin inflammation due to excessive activation of CD8+ T lymphocytes. Further, the severely reduced number of mature NK cells in IRF2-deficient mice suggests that IRF2 is required for normal NK cell development. IRF2 contains a latent activation domain that can act as a transcriptional activator and has been revealed to positively regulate Histone H4 and VCAM-1 gene expression.
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