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IRF2 抗体

This anti-IRF2 antibody is a 小鼠 单克隆 antibody detecting IRF2 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN2665203
发货至: 中国

Quick Overview for IRF2 抗体 (ABIN2665203)

抗原

See all IRF2 抗体
IRF2 (Interferon Regulatory Factor 2 (IRF2))

适用

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人, 小鼠

宿主

  • 78
  • 5
  • 2
  • 1
小鼠

克隆类型

  • 73
  • 13
单克隆

标记

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  • 1
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This IRF2 antibody is un-conjugated

应用范围

  • 62
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Western Blotting (WB)

克隆位点

13B2A38
  • 纯化方法

    The antibody was purified by affinity chromatography.

    亚型

    IgG1 kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    IRF2 (Interferon Regulatory Factor 2 (IRF2))

    别名

    IRF2

    背景

    IRF2 is a member of the IRF family of transcription factors, mainly functioning as a transcriptional repressor. It binds to the interferon-sensitive response elements (ISREs) and competes for binding sites with the other IRF transcription factors, such as IRF1 and IRF9. Mice deficient in IRF2 spontaneously develop skin inflammation due to excessive activation of CD8+ T lymphocytes. Further, the severely reduced number of mature NK cells in IRF2-deficient mice suggests that IRF2 is required for normal NK cell development. IRF2 contains a latent activation domain that can act as a transcriptional activator and has been revealed to positively regulate Histone H4 and VCAM-1 gene expression.
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