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LY75/DEC-205 抗体

This anti-LY75/DEC-205 antibody is a 小鼠 单克隆 antibody detecting LY75/DEC-205 in ICFC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN2664380
发货至: 中国

Quick Overview for LY75/DEC-205 抗体 (ABIN2664380)

抗原

See all LY75/DEC-205 (LY75) 抗体
LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

适用

  • 55
  • 31
  • 8
  • 8
  • 2
人, 小鼠, 大鼠

宿主

  • 41
  • 29
  • 7
  • 3
  • 1
  • 1
小鼠

克隆类型

  • 47
  • 32
  • 2
单克隆

标记

  • 43
  • 9
  • 8
  • 5
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This LY75/DEC-205 antibody is un-conjugated

应用范围

  • 33
  • 27
  • 25
  • 20
  • 15
  • 14
  • 10
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
Intracellular Flow Cytometry (ICFC)

克隆位点

HD83
  • 交叉反应

    纯化方法

    The antibody was purified by affinity chromatography.

    亚型

    IgG1 kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

    别名

    CD205

    背景

    CD205, also known as DEC-205 and LY75, belongs to the macrophage mannose receptor (MMR) family of C-type lectins. Both human and mouse CD205 share multiple similar structures: an N-terminal cysteine-rich domain, a fibronectin type II domain, and a series of 10 tandemly repeated C-type like domains (CTLDs). CD205 is highly expressed on dendritic cells and thymic cortical epithelial cells in humans and mice. It also can be detected on T and B cells, monocytes, neutrophils, and epithelial cells. CD205 is a novel endocytic receptor used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to specialized antigen processing areas. It mediates antigen uptake and presentation and cross-presentation to T cells. It has been reported that CD205 acts as a recognition receptor for dying cells, which potentially provides an important pathway for the uptake of self-antigen in the intrathymic environment, and is involved in peripheral tolerance.
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