PDGFRB 抗体
Quick Overview for PDGFRB 抗体 (ABIN2664224)
抗原
See all PDGFRB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography.
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亚型
- IgG1 kappa
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anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 887-1106) antibody
PDGFRB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 33-133) antibodyPDGFRB 适用: 人 WB, ELISA, IP, PLA 宿主: 小鼠 Monoclonal 4C12 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 981-1066) antibodyPDGFRB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 1-1106) antibodyPDGFRB 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 40-72) antibodyPDGFRB 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 33-133) antibodyPDGFRB 适用: 人, 小鼠 ELISA, FACS 宿主: 小鼠 Monoclonal 2G7B7 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) antibodyPDGFRB 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1G9 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) antibodyMicroarray verified PDGFRB 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB472367 unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 1-1106) antibodyPDGFRB 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Platelet Derived Growth Factor Receptor beta (PDGFRB) (AA 718-767) antibodyPDGFRB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
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别名
- CD140b
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背景
- CD140b is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. The identity of the growth factor bound to the receptor determines whether the functional receptor is a homodimer or heterodimer composed of both PDGFR-α and -β. CD140b contains two immunoglobulin-like domains and a tyrosine kinase domain with a predicted molecular weight approximately 124 kD. CD140b is widely expressed on a variety of mesenchymal-derived cells and is preferentially expressed on some tumors such as medulloblastoma. Binding of B-chain containing PDGF molecules can stimulate cell proliferation. CD140b has been shown to interact with a number of kinases (including Raf-1, NCK1, FAK, Fyn, others) as well as adaptor molecules and signaling intermediates (Crk, Grb2, Grb4, RasGAP, SHP2, SHC1, others), and has also been shown to associate with integrin β3 and nexin sorting molecules. CD140b has been implicated in several disease states including atherogenesis and oncogenesis. The PDGFRβ is heavily phosphorylated on numerous tyrosine residues through both autophosphorylation and ligand-dependent processes.
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
抗原
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