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IL3RA 抗体

IL3RA 适用: 小鼠 FACS, ICFC 宿主: 大鼠 Monoclonal 5B11 unconjugated
产品编号 ABIN2664182
发货至: 中国
  • 抗原 See all IL3RA 抗体
    IL3RA (Interleukin 3 Receptor, alpha (IL3RA))
    适用
    • 78
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    小鼠
    宿主
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    大鼠
    克隆类型
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    单克隆
    标记
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    This IL3RA antibody is un-conjugated
    应用范围
    • 59
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    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    5B11
    亚型
    IgG2a kappa
    Top Product
    Discover our top product IL3RA Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    IL3RA (Interleukin 3 Receptor, alpha (IL3RA))
    别名
    CD123 (IL3RA 产品)
    别名
    CD123 antibody, IL3R antibody, IL3RAY antibody, IL3RX antibody, IL3RY antibody, hIL-3Ra antibody, CDw123 antibody, SUT-1 antibody, Cyrl antibody, interleukin 3 receptor subunit alpha antibody, interleukin 3 receptor, alpha chain antibody, IL3RA antibody, Il3ra antibody
    背景
    CD123 is a 70 kD α chain subunit of the IL-3 receptor (IL-3R α). It is a member of the immunoglobulin superfamily that is expressed on hematopoietic progenitors, basophils, mast cells, and megakaryocytes. This transmembrane glycoprotein can bind IL-3 with low affinity but cannot transduce signals without association with additional protein partners. CD123 can complex with either the common β chain (CDw131) or the IL-3R β chain (AIC2A) to form high-affinity heterodimeric IL-3 receptors. CDw131 can complex with the α subunits of the mouse IL-3R, IL-5R and GM-CSFR to form high-affinity receptors, while the IL-3 R β subunit is specific for IL-3 but binds with low affinity. IL-3 binding to the receptor complex can induce proliferation and differentiation of hematopoietic cells. The 5B11 antibody does not block binding of IL-3 to the high affinity IL-3 receptor.
    途径
    JAK/STAT Signaling
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