TCL1A 抗体 (PE)
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北京 101111
Quick Overview for TCL1A 抗体 (PE) (ABIN2663891)
抗原
See all TCL1A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
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亚型
- IgG2b kappa
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anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 2-109) antibody
TCL1A 适用: 人 IHC, WB, StM 宿主: 小鼠 Monoclonal TCL1-2079 unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 2-109) antibodyTCL1A 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TCL1-2078 unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 10-104) antibodyTCL1A 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2E3A5 unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 1-114) antibodyTCL1A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 61-114) antibodyTCL1A 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 61-114) antibodyTCL1A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G10 unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 61-114) antibodyTCL1A 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 2-109) antibodyTCL1A 适用: 人 IHC, StM 宿主: 兔 Monoclonal TCL1-2747R unconjugated Recombinant Antibody
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 1-114) antibodyTCL1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-T-Cell Leukemia/lymphoma 1A (TCL1A) (AA 1-90) antibodyTCL1A 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from prolonged exposure to light. Do not freeze.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))
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别名
- TCL1
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背景
- TCL1, also known as T-cell leukemia/lymphoma protein 1A, protein p14 TCL1 and oncogene TCL-1, is a 14kD beta-barrel protein that was originally identified on the basis of its association with T-cell prolymphocytic leukemia (T-PLL). Activated by the T-cell receptor enhancer through inv(14)(q11,q32.1) or t(14,14)(q11,q32.1), TCL1 is normally expressed in immature cortical thymocytes, activated peripheral T-cells, pro-B cells, and naive mantle zone B cells of peripheral lymphoid tissues, but not in post-germinal center (GC) memory B cells and plasma cells. Akt and TCL1 interact via Akt's pleckstrin homology domain to form hetero-oligomers at the leaflet of the inner plasma membrane stimulating the protein kinase C-mitogen activated protein kinase-extracellular signal-related kinase (PKC-MAPK-ERK) signal transduction pathway. TCL1 also inhibits activation-induced cell death in T-cells by blocking PKCθ. In addition to T-PLL dysregulation is implicated in such B-cell neoplasias as lymphoblastic lymphoma, chronic lymphocytic leukemia (CLL) and Burkitt lymphoma.
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途径
- Stem Cell Maintenance
抗原
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