IL-33 抗体 (AA 112-270) (Biotin)
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- 抗原 See all IL-33 (IL33) 抗体
- IL-33 (IL33) (Interleukin 33 (IL33))
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抗原表位
- AA 112-270
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适用
- 人
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This IL-33 antibody is conjugated to Biotin
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应用范围
- Flow Cytometry (FACS)
- 交叉反应 (详细)
- In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.
- 纯化方法
- The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
- 免疫原
- AA 112-270 (Accession# NM_033439) was expressed in E. coli.
- 克隆位点
- Poly5163
- 亚型
- Ig Fraction, IgG
- Top Product
- Discover our top product IL33 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.2 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- 抗原
- IL-33 (IL33) (Interleukin 33 (IL33))
- 别名
- IL-33 (IL33 产品)
- 背景
- IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.
- 途径
- Production of Molecular Mediator of Immune Response
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