IL-33 抗体 (AA 112-270) (Biotin)
Quick Overview for IL-33 抗体 (AA 112-270) (Biotin) (ABIN2661328)
抗原
See all IL-33 (IL33) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 112-270
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交叉反应 (详细)
- In sandwich ELISA, no cross-reactivity with mouse or rat IL-33.
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纯化方法
- The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
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免疫原
- AA 112-270 (Accession# NM_033439) was expressed in E. coli.
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亚型
- Ig Fraction, IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- IL-33 (IL33) (Interleukin 33 (IL33))
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别名
- IL-33
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背景
- IL-33, also known as NFHEV and DVS 27, is a 30 kD proinflammatory protein that belongs to IL-1 superfamily. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1α or IL-1β stimulation. IL-33 interacts with IL1RL1/ST2 receptor and IL-1 receptor accessory protein (IL1RAP) in order to activate intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. Recombinant IL-33 has been shown to enhance Th2-associated immune responses and potently increase mast cell proliferation and cytokine production.
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途径
- Production of Molecular Mediator of Immune Response
抗原
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