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CD93 抗体 (PE-Cy7)

This anti-CD93 antibody is a 大鼠 单克隆 antibody detecting CD93 in FACS. Suitable for 小鼠.
产品编号 ABIN2659569
发货至: 中国

Quick Overview for CD93 抗体 (PE-Cy7) (ABIN2659569)

抗原

See all CD93 抗体
CD93

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This CD93 antibody is conjugated to PE-Cy7

应用范围

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Flow Cytometry (FACS)

克隆位点

AA4-1
  • 纯化方法

    The antibody was purified by affinity chromatography, and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.

    亚型

    IgG2b kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    0.2 mg/mL

    缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from prolonged exposure to light. Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    CD93

    别名

    CD93

    物质类

    Chemical

    背景

    CD93 is a 130-140kD C-type lectin-like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen. It is a receptor expressed on immature B lymphocytes, hematopoietic progenitors and stem cells in adult bone marrow, fetal liver, and embryonic yolk sac. CD93 expression levels on splenic immature/transitional B cells is much lower than in bone marrow. It is reinduced during plasma cell differentiation and plays an important role in maintaining plasma cells in bone marrow niches. Immature dendritic cells express CD93 and down-regulate this molecule upon maturation, suggesting a role in uptake of particles by DC. It is also expressed on monocytes, macrophages, and endothelial cells. Macrophages from CD93 (-/-) mice had a significant phagocytic defect in the clearance of apoptotic cells in vivo, indicating CD93 may contribute to the in vivo clearance of dying cells. Binding of CD93 to C1q remains controversial.
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