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Fc epsilon RI/FCER1A 抗体 (PE-Cy7)

This PE-Cy7-conjugated 小鼠 单克隆 anti-Fc epsilon RI/FCER1A antibody (Clone AER-37 (CRA-1)) specifically detects Fc epsilon RI/FCER1A in FACS. The antibody is reactive with 人 samples.
产品编号 ABIN2659347
发货至: 中国
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Quick Overview for Fc epsilon RI/FCER1A 抗体 (PE-Cy7) (ABIN2659347)

抗原

See all Fc epsilon RI/FCER1A (FCER1A) 抗体
Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Fc epsilon RI/FCER1A antibody is conjugated to PE-Cy7

应用范围

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Flow Cytometry (FACS)

克隆位点

AER-37 (CRA-1)
  • 纯化方法

    The antibody was purified by affinity chromatography and conjugated with PE/Cy7 under optimal conditions. The solution is free of unconjugated PE/Cy7 and unconjugated antibody.

    亚型

    IgG2b kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from prolonged exposure to light. Do not freeze.

    储存条件

    4 °C

    储存方法

    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原

    Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

    别名

    Fc epsilon RI alpha

    背景

    High affinity IgE receptor (FcεRI) plays a key role in IgE-mediated allergic immune response. FcεRI is a tetrameric receptor complex, which is composed of one α-subunit (FcεRIα), one β-subunit, and two γ-subunits. FcεRIα directly binds IgE with high affinity, while the β- and γ-chains are responsible for mediating intracellular signals. FcεRIα is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcεRIα is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients.

    途径

    Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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