IL-27 抗体 (Alexa Fluor 647)
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- 抗原 See all IL-27 (IL27) 抗体
- IL-27 (IL27) (Interleukin 27 (IL27))
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IL-27 antibody is conjugated to Alexa Fluor 647
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应用范围
- Flow Cytometry (FACS)
- 纯化方法
- The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
- 克隆位点
- MM27-7B1
- 亚型
- IgG2a
- Top Product
- Discover our top product IL27 Primary Antibody
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anti-Interleukin 27 (IL27) (AA 177-243) antibody
IL27 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F12 unconjugated
anti-Interleukin 27 (IL27) (C-Term) antibodyIL27 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 1-243) antibodyIL27 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 1-243) antibodyIL27 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (N-Term) antibodyIL27 适用: 人, 小鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 57-87) antibodyIL27 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB3263 unconjugated
anti-Interleukin 27 (IL27) antibodyIL27 适用: 小鼠 WB, ELISA, FACS, MA 宿主: 大鼠 Monoclonal 3H12-F10 unconjugated
anti-Interleukin 27 (IL27) (AA 29-243) antibodyIL27 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) (AA 31-46) antibodyIL27 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 27 (IL27) antibodyIL27 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal B-G49 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Protect from prolonged exposure to light. Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C
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- 抗原
- IL-27 (IL27) (Interleukin 27 (IL27))
- 别名
- IL-27 p28 (IL27 产品)
- 背景
- IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40-related protein) and p28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naive CD4+ T cells, and promotes Th1 polarization and IFN-γ production in synergy with IL-12. The IL-27-induced Th1 differentiation was mediated by rapid and marked upregulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 exhibits anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation. It also plays a potential therapeutic role in autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rβ2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27.
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