GUCY1B3 抗体
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Quick Overview for GUCY1B3 抗体 (ABIN265451)
抗原
See all GUCY1B3 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects endogenous levels of Guanylate Cyclase β1/3 protein. (region surrounding Val21)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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纯度
- > 95 % pure by SDS-PAGE
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anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (AA 408-619) antibody
GUCY1B3 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (N-Term) antibodyGUCY1B3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) antibodyGUCY1B3 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) antibodyGUCY1B3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (N-Term) antibodyGUCY1B3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (AA 1-250) antibodyGUCY1B3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (AA 10-59) antibodyGUCY1B3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (AA 188-207) antibodyGUCY1B3 适用: 人, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (N-Term) antibodyGUCY1B3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3) (AA 180-229) antibodyGUCY1B3 适用: 人, 小鼠, 犬, Cow, 豚鼠, 兔, Pig, 马, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1: 5000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- DO NOT FREEZE!
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- GUCY1B3 (Guanylate Cyclase 1, Soluble, beta 3 (GUCY1B3))
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别名
- Guanylate Cyclase Soluble GUCY1B3
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背景
- Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.Synonyms: GCS-beta-1, GCS-beta-3, GUC1B3, GUCSB3, GUCY1B1, Guanylate cyclase soluble subunit beta-1, Guanylate cyclase soluble subunit beta-3, Soluble guanylate cyclase small subunit, sGC beta
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分子量
- approx. 70 kDa
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基因ID
- 2983
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NCBI登录号
- NP_000848
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UniProt
- Q02153
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途径
- Transition Metal Ion Homeostasis
抗原
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