SULF2 抗体
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北京 101111
Quick Overview for SULF2 抗体 (ABIN265174)
抗原
See all SULF2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects Sulf2. Antibody tested on human brain lysate.
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纯化方法
- Purified
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免疫原
- Synthetic peptide derived from the human Sulf2 protein
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亚型
- IgG
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应用备注
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Western blot (0.05-0.1 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- Phosphate buffered saline with 0.08 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
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- SULF2 (Sulfatase 2 (SULF2))
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别名
- SULF2
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背景
- Sulf-2 exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Mammalian Sulfs are endoproteolytically processed and secreted into the extracellular space of transfected cells, where they exhibit both arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity against intact heparin. Though the molecular weight of full length human Sulf2 is 100455 Da (870 amino acids), the endogenous Sulf2 is found by western blot to be present at molecular weights of 24.4, 33.7 and 51-60 kDa. Higher molecular weight species may be found depending on tissue and/or cell type. Analysis of human tumor tissue and tumor cell lines suggests that HSulf-1 is misregulated in cancers. HSulf-1 is found in a variety of normal tissues but is down-regulated in tumor cell lines originating from ovarian, breast, pancreatic, renal, and hepatocellular carcinoma. Tumors formed by cells expressing Sulf demonstrate enhanced extracellular matrix deposition. The 6-O-sulfation of heparan sulfate of myeloma tumor cells may be a critical factor in determiningand regulating the in vivo growth of this cancer.Synonyms: Extracellular sulfatase Sulf-2, KIAA1247
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基因ID
- 55959
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NCBI登录号
- NP_001155313
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UniProt
- Q8IWU5
抗原
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