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SULF2 抗体

This 兔 多克隆 antibody specifically detects SULF2 in WB. It exhibits reactivity toward 人.
产品编号 ABIN265174
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SULF2 抗体 (ABIN265174)

抗原

See all SULF2 抗体
SULF2 (Sulfatase 2 (SULF2))

适用

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宿主

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克隆类型

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多克隆

标记

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This SULF2 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 特异性

    This antibody detects Sulf2. Antibody tested on human brain lysate.

    纯化方法

    Purified

    免疫原

    Synthetic peptide derived from the human Sulf2 protein

    亚型

    IgG
  • 应用备注

    Western blot (0.05-0.1 μg/mL).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.08 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  • 抗原

    SULF2 (Sulfatase 2 (SULF2))

    别名

    SULF2

    背景

    Sulf-2 exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Mammalian Sulfs are endoproteolytically processed and secreted into the extracellular space of transfected cells, where they exhibit both arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity against intact heparin. Though the molecular weight of full length human Sulf2 is 100455 Da (870 amino acids), the endogenous Sulf2 is found by western blot to be present at molecular weights of 24.4, 33.7 and 51-60 kDa. Higher molecular weight species may be found depending on tissue and/or cell type. Analysis of human tumor tissue and tumor cell lines suggests that HSulf-1 is misregulated in cancers. HSulf-1 is found in a variety of normal tissues but is down-regulated in tumor cell lines originating from ovarian, breast, pancreatic, renal, and hepatocellular carcinoma. Tumors formed by cells expressing Sulf demonstrate enhanced extracellular matrix deposition. The 6-O-sulfation of heparan sulfate of myeloma tumor cells may be a critical factor in determiningand regulating the in vivo growth of this cancer.Synonyms: Extracellular sulfatase Sulf-2, KIAA1247

    基因ID

    55959

    NCBI登录号

    NP_001155313

    UniProt

    Q8IWU5
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