Adiponectin Receptor 1 抗体
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北京 101111
Quick Overview for Adiponectin Receptor 1 抗体 (ABIN265109)
抗原
See all Adiponectin Receptor 1 (ADIPOR1) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody recognizes Adiponectin Receptor 1.
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纯化方法
- Ammonium Sulfate Precipitation
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免疫原
- Synthetic peptide derived from Human Adiponectin Receptor 1 protein.
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应用备注
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Western Blot: 5-10 μg/mL. Positive Control: Highly expressed in skeletal muscle. Expressed at intermediate level inbrain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Phosphate buffered saline with 0.08 % Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- Adiponectin Receptor 1 (ADIPOR1)
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别名
- Adiponectin Receptor 1
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背景
- Alzheimer's disease (AD) is characterized by formation of plaques of amyloid beta peptide (Abeta). Autosomally-inherited AD had been shown only in connection with coding sequence mutations. Likely transcription factors whose mutation can cause loss of function are ADR1, MIG1, and PuF, and for gain of function, E12/E47, ITF-2, and RFX2. Adr1 controls the expression of genes required for ethanol, glycerol, and fatty acid utilization (in yeast). Adr1 can act directly on the promoters of ADH2, ACS1, GUT1, CTA1, and POT1. The yeast homolog of the AMP-activated protein kinase, Snf1, promotes Adr1 chromatin binding in the absence of glucose, and the protein phosphatase complex, Glc7.Reg1, represses its binding in the presence of glucose. A post-translational process is invloved in the regulation of Adr1 binding. Chromatin binding by Adr1 is not the only step in ADH2 transcription that is regulated by glucose repression, Adr1 can bind to chromatin in repressed conditions in the presence of hyperacetylated histones. In yeast, nuclear extracts prepared from glucose-repressed and glucosederepressed cells are equally capable of supporting miniAdr1-dependent transcription and pre-initiation complex formation.Synonyms: ADIPOR1, CGI-45, PAQR1, Progestin and adipoQ receptor family member I
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基因ID
- 51094
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NCBI登录号
- NP_001121159
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UniProt
- Q96A54
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途径
- AMPK Signaling
抗原
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