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EDG4 抗体 (N-Term)

This anti-EDG4 antibody is a 兔 多克隆 antibody detecting EDG4 in WB. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN265051
发货至: 中国

Quick Overview for EDG4 抗体 (N-Term) (ABIN265051)

抗原

See all EDG4 (LPAR2) 抗体
EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

适用

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宿主

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克隆类型

  • 67
多克隆

标记

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This EDG4 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    特异性

    This antibody recognizes Human EDG-4 / LPA2. Other species not tested.

    纯化方法

    Purified

    免疫原

    Antibody raised against a unique synthetic peptide derived from the N-terminal of the human EDG4 protein.

    亚型

    IgG
  • 应用备注

    Western Blot: 5 - 10 μg/mL, should be visualized using a high sensitivitysecondary/substrate system (i. e. Pierce's SuperSignal West Femto Maximum SensitivitySubstrate).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS, 0.08 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • Iwai, Koike, Ohshima, Miyatake, Uchiyama, Saeki, Ishii: "RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, Issue 10, pp. 1612-20, (2007) (PubMed).

    Jayapal, Tay, Reghunathan, Zhi, Chow, Rauff, Melendez: "Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcepsilonRI-aggregation reveals a complex network of genes involved in inflammatory responses." in: BMC genomics, Vol. 7, pp. 210, (2006) (PubMed).

    Shida, Watanabe, Aoki, Hama, Kitayama, Sonoda, Kishi, Yamaguchi, Sasaki, Sako, Konishi, Arai, Nagawa: "Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 84, Issue 10, pp. 1352-62, (2004) (PubMed).

  • 抗原

    EDG4 (LPAR2) (Lysophosphatidic Acid Receptor 2 (LPAR2))

    别名

    EDG-4 / LPAR2

    背景

    EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG4 is lysophospholipid. There are 6 known members of the EDG receptor family and they are implicated in mediating growthrelated effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG4 is expressed in testes, ovarian tumor and leukocyte containing tissues.Synonyms: EDG4, Ipa-2, LPAR2, Lysophosphatidic acid receptor 2, Lysophosphatidic acid receptor Edg-4, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

    基因ID

    9170

    NCBI登录号

    NP_004711

    UniProt

    Q9HBW0
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