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RIT1 抗体

The 兔 多克隆 anti-RIT1 antibody (ABIN265014) specifically detects RIT1 in WB. The antibody is reactive with 人 samples.
产品编号 ABIN265014
发货至: 中国
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Quick Overview for RIT1 抗体 (ABIN265014)

抗原

See all RIT1 抗体
RIT1 (Ras-Like Without CAAX 1 (RIT1))

适用

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宿主

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克隆类型

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多克隆

标记

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This RIT1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 特异性

    This antibody reacts to RIT1.

    纯化方法

    Purified

    免疫原

    His-tagged recombinant human Rit protein

    亚型

    IgG
  • 应用备注

    Western Blot: detects recombinant Rit protein expressed in HEK-293 cells, Shows minimalcross-reactivity with Rin protein and other Ras proteins.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.08 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
  • 抗原

    RIT1 (Ras-Like Without CAAX 1 (RIT1))

    别名

    RIT1

    背景

    Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64 % amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100 % conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.Synonyms: RIBB, RIT, ROC1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1

    基因ID

    6016

    NCBI登录号

    NP_008843

    UniProt

    Q92963

    途径

    Neurotrophin Signaling Pathway
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