S1PR4 抗体 (C-Term)
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Quick Overview for S1PR4 抗体 (C-Term) (ABIN265012)
抗原
See all S1PR4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody recognizes Human EDG-6 / S1P4 / S1PR4. Other species not tested.
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纯化方法
- Purified
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免疫原
- Synthetic peptide derived from the C-terminal of the EDG-6 receptor.
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应用备注
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Western Blot: Detects EDG-6 receptors at concentration of 5-10 μg/mL by Western blotusing a human EDG-6 receptor transfected cell line. Detects an approximately 45 kDa bandin Cos cells transfected with full length human EDG-6. Due to low expression of EDGreceptors, we recommend use of Pierce Femto Signal substrate for western blotdevelopment.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS, 0.08 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))
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别名
- S1PR4 / EDG6
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背景
- EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).Synonyms: EDG-6, Endothelial differentiation G-protein coupled receptor 6, S1P receptor Edg-6, Sphingosine 1-phosphate receptor 4, Sphingosine 1-phosphate receptor Edg-6
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基因ID
- 8698
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NCBI登录号
- NP_003766
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UniProt
- O95977
抗原
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