KLRB1B 抗体
KLRB1B
适用: 小鼠
FACS, IP, WB
宿主: 小鼠
Monoclonal
1C10
unconjugated
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- 抗原 See all KLRB1B products
- KLRB1B (Killer Cell Lectin-Like Receptor Subfamily B Member 1B (KLRB1B))
- 适用
- 小鼠
- 宿主
- 小鼠
- 克隆类型
- 单克隆
- 应用范围
- Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
- 产品特性
- Synonyms: NKRP1, Klrb1c NKR-P1
- 纯化方法
- Purified
- 免疫原
- Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c XC57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cell line.
- 克隆位点
- 1C10
- 亚型
- IgG
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- 应用备注
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Western Blot (1-5 μg/mL). Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.08 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
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Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. - 有效期
- 12 months
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- 抗原
- KLRB1B (Killer Cell Lectin-Like Receptor Subfamily B Member 1B (KLRB1B))
- 别名
- Natural Killer Cell Receptor-P1 (KLRB1B 产品)
- 别名
- Klrb1d antibody, Ly55b antibody, Ly55d antibody, NKR-P1B antibody, NKR-P1D antibody, Nkrp1-b antibody, Nkrp1d antibody, Nkr-p1b antibody, Nkrp1b antibody, killer cell lectin-like receptor subfamily B member 1B antibody, Klrb1b antibody
- 背景
- Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10 % of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.Synonyms: Klrb1c NKR-P1, NKRP1
- UniProt
- Q61970
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