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HSP70 抗体 (FITC)

Name: HSP70 抗体 (FITC)
SKU: ABIN263935
Availability: OutOfStock

This 小鼠单克隆 antibody specifically detects HSP70 in FACS. It exhibits reactivity toward 人, 小鼠, 大鼠, 小鸡, Drosophila melanogaster, Cow, Pig, 猴, 犬, Hamster, 绵羊, 豚鼠, 兔和 Carp. It has been mentioned in 9+ publications

FACS

1 image

(9 references)

产品编号 ABIN263935

发货至: 中国

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Quick Overview for HSP70 抗体 (FITC) (ABIN263935)

抗原

See all HSP70 抗体

HSP70 (Heat Shock Protein 70 (HSP70))

适用

人, 小鼠, 大鼠, 小鸡, Drosophila melanogaster, Cow, Pig, 猴, 犬, Hamster, 绵羊, 豚鼠, 兔, Carp

宿主

小鼠

克隆类型

单克隆

标记

This HSP70 antibody is conjugated to FITC

应用范围

Flow Cytometry (FACS)

克隆位点

C92F3A-5

Discover our top product HSP70 Primary Antibody

特异性

This antibody detects a ~70 kDa protein corresponding to the Molecular Mass of inducible HSP70 on SDS PAGE Immunoblots. The mapped epitope is in the region of amino acid residues 436-503. Does not cross-react with HSC70 (HSP73).

产品特性

Synonyms: HSP70.1, HSP70-1/HSP70-2, HSPA1A, HSPA1B, HSPA1, Heat shock 70 kDa protein 1A/1B

纯化方法

Affinity Chromatography on Protein G

免疫原

Human Hsp70 (1)

亚型

IgG1
anti-Heat Shock Protein 70 (HSP70) antibody
HSP70 适用: 人 WB, IHC, ELISA, IF, ICC, FACS, IEM, AA, BI 宿主: 小鼠 Monoclonal C92F3A-5 unconjugated

anti-Heat Shock Protein 70 (HSP70) antibody
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Heat Shock Protein 70 (HSP70) antibody (HRP)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal HRP

anti-Heat Shock Protein 70 (HSP70) antibody (FITC)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal FITC

anti-Heat Shock Protein 70 (HSP70) antibody (Biotin)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal Biotin

anti-Heat Shock Protein 70 (HSP70) antibody (PE)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal PE

anti-Heat Shock Protein 70 (HSP70) antibody (APC)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal APC

anti-Heat Shock Protein 70 (HSP70) antibody (PerCP)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal PerCP

anti-Heat Shock Protein 70 (HSP70) antibody (Atto 594)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal Atto 594

anti-Heat Shock Protein 70 (HSP70) antibody (Atto 488)
HSP70 适用: 人 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal Atto 488

应用备注

FACS (12). Flow cytometry.

限制

仅限研究用
浓度

0.33 mg/mL

缓冲液

PBS, pH 7.2, 0.01 % Sodium Azide, 50 % Glycerol

储存液

Sodium azide

注意事项

WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

注意事项

DO NOT FREEZE! This product is photosensitive and should be protected from light.

储存条件

4 °C

储存方法

Store the antibody at 2 - 8 °C.
Shelf life: one year from despatch.

有效期

12 months
Aare, Radell, Eriksson, Akkad, Chen, Hoffman, Larsson: "Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model." in: Physiological genomics, Vol. 45, Issue 8, pp. 312-20, (2013) (PubMed).

Bauckman, Haller, Flores, Nanjundan: "Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells." in: Cell death & disease, Vol. 4, pp. e592, (2013) (PubMed).

Nelson, Manhardt, Kamath, Sui, Santamaria-Pang, Can, Bello, Corwin, Dinn, Lazare, Gervais, Sequeira, Peters, Ginty, Gerdes, Larsen: "Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation." in: Biology open, Vol. 2, Issue 5, pp. 439-47, (2013) (PubMed).

Cheng, Djajadi, Molday: "Cell-specific markers for the identification of retinal cells by immunofluorescence microscopy." in: Methods in molecular biology (Clifton, N.J.), Vol. 935, pp. 185-99, (2012) (PubMed).

Orr, Haffner, Nelson, Yegnasubramanian, Eberhart: "Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma." in: PLoS ONE, Vol. 7, Issue 7, pp. e41036, (2012) (PubMed).

Fang, Liu, Lin, Fan, Tsai, Tzeng: "Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway." in: Journal of cellular biochemistry, Vol. 113, Issue 9, pp. 3019-28, (2012) (PubMed).

Gui, Xiong, Yang, Li, Huang: "Effects of acupuncture on LIF and IL-12 in rats of implantation failure." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 67, Issue 5, pp. 383-90, (2012) (PubMed).

Simão, Yadav, Narisawa, Bolean, Pizauro, Hoylaerts, Ciancaglini, Millán: "Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics." in: The Journal of biological chemistry, Vol. 285, Issue 10, pp. 7598-609, (2010) (PubMed).

Miyoshi, Kasahara, Miyazaki, Shimizu, Taniguchi, Matsuzaki, Tohyama, Asanuma: "Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 10, pp. 3289-97, (2009) (PubMed).
抗原

HSP70 (Heat Shock Protein 70 (HSP70))

别名

Heat Shock Protein 70 / HSP70

背景

Hsp70 genes encode abundant heat-inducible 70- kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 5O% identity (2). The N-terminal two thirds of hsp70s are more conserved than the C-terminal third. Hsp70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When hsc70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44 kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (5). All hsp70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the hsp70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of hsp70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport.Synonyms: HSP70-1/HSP70-2, HSP70.1, HSPA1, HSPA1A, HSPA1B, Heat shock 70 kDa protein 1A/1B

基因ID

3303

UniProt

P08107