PKA alpha/beta Cat (pThr197) 抗体
Quick Overview for PKA alpha/beta Cat (pThr197) 抗体 (ABIN2568430)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pThr197
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特异性
- The antibody detects endogenous levels of PKA alpha/beta CAT only when phosphorylated at threonine 197.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- PKA alpha/beta CAT (phospho Thr197) antibody was raised against a peptide sequence around phosphorylation site of threonine 197 (R-T-W (p)-T-L) derived from Human PKA alpha/beta CAT.
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亚型
- IgG
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anti-PKA alpha/beta Cat (pThr197) antibody
适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-PKA alpha/beta Cat (N-Term) antibody适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-PKA alpha/beta Cat (AA 166-215) antibody适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- PKA alpha/beta Cat
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背景
- Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts.
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分子量
- 40 kDa
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基因ID
- 5566
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NCBI登录号
- NP_002721
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UniProt
- P17612
抗原
-
