The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein.
纯化方法
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
Phosphate-buffered aqueous solution, ph7.2.
储存条件
4 °C
储存方法
The product should be stored undiluted at 4°C. Do not freeze.
抗原
ITGAL
(Integrin alpha-L (ITGAL))
别名
CD11a
背景
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein. CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1). LFA-1 is expressed on all leukocytes and is involved in intercellular adhesions. The M17/4 antibody blocks many of the LFA-1 mediated cell interaction and in vivo it prolongs allograft survival, inhibits the autoimmune response, and reduces graft versus host reactions.