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P4HB 抗体 (AA 409-509) (APC)

P4HB 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 兔 Polyclonal APC
产品编号 ABIN2486774
发货至: 中国
  • 抗原 See all P4HB 抗体
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    抗原表位
    • 20
    • 19
    • 15
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 409-509
    适用
    • 106
    • 73
    • 63
    • 23
    • 22
    • 20
    • 20
    • 18
    • 18
    • 16
    • 10
    • 10
    • 8
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 117
    • 25
    • 2
    克隆类型
    • 108
    • 36
    多克隆
    标记
    • 61
    • 16
    • 15
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This P4HB antibody is conjugated to APC
    应用范围
    • 110
    • 67
    • 44
    • 43
    • 42
    • 35
    • 18
    • 15
    • 14
    • 13
    • 13
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Detects ~58 kDa.
    交叉反应
    Cow, 犬, 豚鼠, Hamster, 人, Mollusca, 小鼠, Pig, 大鼠, 绵羊, 非洲爪蟾
    纯化方法
    Peptide Affinity Purified
    免疫原
    Rat PDI synthetic peptide (409-509 aa C-terminal) conjugated to KLH
    Top Product
    Discover our top product P4HB Primary Antibody
  • 应用备注
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    说明

    A 1:1000 dilution of ABIN2486774 was sufficient for detection of PDI in 20 μg of HeLa cell lysate by ECL immunoblot analysis.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    别名
    PDI (P4HB 产品)
    别名
    DSI antibody, ERBA2L antibody, GIT antibody, P4Hbeta antibody, PDI antibody, PDIA1 antibody, PHDB antibody, PO4DB antibody, PO4HB antibody, PROHB antibody, PDA2 antibody, PDIP antibody, PDIR antibody, ERp59 antibody, Pdia1 antibody, Thbp antibody, p55 antibody, XPDIp antibody, pdi antibody, 1810041F13Rik antibody, AI661267 antibody, Pdip antibody, Pdipl antibody, p58 antibody, prolyl 4-hydroxylase subunit beta antibody, protein disulfide isomerase family A member 2 antibody, prolyl 4-hydroxylase, beta polypeptide antibody, protein disulfide isomerase family A member 2 L homeolog antibody, protein disulfide isomerase associated 2 antibody, prolyl 4-hydroxylase subunit beta L homeolog antibody, protein disulfide-isomerase antibody, P4HB antibody, PDIA2 antibody, P4hb antibody, pdia2.L antibody, Pdia2 antibody, p4hb.L antibody, LOC8281065 antibody
    背景
    The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation via its oxidase activity and isomerization via its isomerase activity, as well as the reduction of disulphide bonds in proteins (1). Studies suggest BiP and PDI work together sequentially to increase oxidation of these proteins (2, 3). PDI has also been found to function as a chaperone to prevent the aggregation of unfolded substrates, and serves as a subunit of prolyl 4-hydroxylase and microsomal triglyceride transferase (4, 5). PDI is an abundant 55 kDa protein located primarily in the ER, however studies have also proved its presence in the cytosol (1). PDI has the ability to reside in the ER permanently due to the highly conserved KDEL sequence at its carboxy-terminus (6). It uses carboxy-terminal KDEL as a retention signal, and this appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor (7).
    基因ID
    287164
    NCBI登录号
    NP_001099245
    UniProt
    P04785
    途径
    Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism
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