SPTBN4 抗体 (AA 1621-1832) (Biotin)
Quick Overview for SPTBN4 抗体 (AA 1621-1832) (Biotin) (ABIN2485674)
抗原
See all SPTBN4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1621-1832
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特异性
- Detects ~>200 kDa. Does not cross react with other Beta-spectrins
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Protein G Purified
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免疫原
- Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin
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亚型
- IgG1
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应用备注
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- WB (1:1000)
- optimal dilutions for assays should be determined by the user.
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说明
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A 1:100 dilution of ABIN2485674 was sufficient for detection of Beta 4 Spectrin in 20 μg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Conjugated antibodies should be stored at 4°C
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- SPTBN4 (Spectrin Beta, Non-Erythrocytic 4 (SPTBN4))
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别名
- beta 4 Spectrin
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背景
- Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart (1). Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier (2).
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基因ID
- 57731
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NCBI登录号
- NP_066022
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UniProt
- Q9H254
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途径
- Sensory Perception of Sound, Regulation of Actin Filament Polymerization, Maintenance of Protein Location
抗原
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