Bassoon 抗体 (AA 786-1041) (FITC)
Quick Overview for Bassoon 抗体 (AA 786-1041) (FITC) (ABIN2484543)
抗原
See all Bassoon (BSN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 786-1041
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特异性
- Detects ~420 kDa. Multiple isoforms can be detected.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Protein A Purified
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免疫原
- NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein
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应用备注
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- WB (1:1000)
- IHC (1:400)
- optimal dilutions for assays should be determined by the user.
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说明
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1 μg/ml of ABIN2484543 was sufficient for detection of Bassoon in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Conjugated antibodies should be stored at 4°C
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- Bassoon (BSN)
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别名
- Bassoon
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背景
- Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
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基因ID
- 8927
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NCBI登录号
- NP_003449
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UniProt
- Q9UPA5
抗原
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