Bassoon 抗体 (AA 786-1041) (Atto 390)
Quick Overview for Bassoon 抗体 (AA 786-1041) (Atto 390) (ABIN2484532)
抗原
See all Bassoon (BSN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - AA 786-1041
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特异性
 - Detects ~420 kDa. Multiple isoforms can be detected.
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交叉反应
 - 人, 小鼠, 大鼠
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纯化方法
 - Protein A Purified
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免疫原
 - NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein
 
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应用备注
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- WB (1:1000)
 - IHC (1:400)
 - optimal dilutions for assays should be determined by the user.
 
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说明
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1 μg/ml of ABIN2484532 was sufficient for detection of Bassoon in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - 4 °C
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储存方法
 - Conjugated antibodies should be stored at 4°C
 
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- Bassoon (BSN)
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别名
 - Bassoon
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背景
 - Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntington, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to co-localize with GABA (A) and glutamate (GluR1) receptors (1).
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基因ID
 - 8927
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NCBI登录号
 - NP_003449
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UniProt
 - Q9UPA5
 
抗原
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