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PDIA3 抗体 (PerCP)

This anti-PDIA3 antibody (ABIN2484410) is a Mouse Monoclonal antibody detecting PDIA3 in WB, IHC, IF, IP, ICC. Suitable for Human.
产品编号 ABIN2484410
发货至: 中国

Quick Overview for PDIA3 抗体 (PerCP) (ABIN2484410)

抗原

See all PDIA3 抗体
PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))

适用

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宿主

  • 75
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小鼠

克隆类型

  • 70
  • 37
单克隆

标记

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This PDIA3 antibody is conjugated to PerCP

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

克隆位点

Map-ERp57
  • 特异性

    Detects ~57 kDa.

    交叉反应

    Cow, 犬, 豚鼠, Hamster, 人, 猴, 小鼠, Pig, 兔, 大鼠

    纯化方法

    Protein G Purified

    免疫原

    Human recombinant ERp57 (Grp58)

    亚型

    IgG1
  • 应用备注

    • WB (1:2000)
    • IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.

    说明

    0.5 μg/ml of ABIN2484410 was sufficient for detection of ERp57 in 10 μg of heat shock Heal Lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Conjugated antibodies should be stored at 4°C
  • 抗原

    PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))

    别名

    ERp57

    背景

    ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).

    基因ID

    2923

    NCBI登录号

    NP_005304

    UniProt

    P30101

    途径

    Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis
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