HCN2 抗体 (AA 761-863) (HRP)
Quick Overview for HCN2 抗体 (AA 761-863) (HRP) (ABIN2481388)
抗原
See all HCN2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 761-863
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特异性
- Detects ~95 kDa. No cross-reactivity against HCN1.
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Protein G Purified
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免疫原
- Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2
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亚型
- IgG1
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anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody
HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 unconjugated
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (FITC)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 FITC
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (Biotin)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 Biotin
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (PE)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 PE
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (APC)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 APC
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (PerCP)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 PerCP
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (Atto 488)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 Atto 488
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (Atto 594)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 Atto 594
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 761-863) antibody (Atto 390)HCN2 适用: 大鼠 WB, IHC, IP, IF, ICC, AA 宿主: 小鼠 Monoclonal S71 Atto 390
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2) (AA 147-161), (Intracellular) antibodyKO Validated HCN2 适用: 人 WB, IHC, IP, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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- WB (1:1000)
- IHC (1:1000)
- ICC/IF (1:100)
- optimal dilutions for assays should be determined by the user.
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说明
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1 μg/ml of ABIN2481388 was sufficient for detection of HCN2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Conjugated antibodies should be stored at 4°C
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- HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))
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别名
- HCN2
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背景
- Hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).
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基因ID
- 114244
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NCBI登录号
- NP_446136
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UniProt
- Q9JKA9
抗原
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