Cullin 3 抗体 (N-Term)
Quick Overview for Cullin 3 抗体 (N-Term) (ABIN2470220)
抗原
See all Cullin 3 (CUL3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- Delipidation and Defibrination
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免疫原
- Cullin 3 antibody was raised against amino acids 1-12 from the N-Terminus of Cullin 3 (Human).
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应用备注
- Cullin 3 antibody can be used in ELISA starting at 1:1000, and immunohistochemistry starting at 10 μg/mL.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.01 % Sodium azide
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注意事项
- As with all antibodies avoid freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store Cullin 3 antibody at 4 °C or -20 °C.
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- Cullin 3 (CUL3)
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别名
- Cullin 3
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背景
- Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.
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基因ID
- 8452
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UniProt
- Q13618
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途径
- M Phase
抗原
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