CBLC
适用: 人
WB, IF, IC
宿主: 兔
Polyclonal
unconjugated
应用备注
CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.
限制
仅限研究用
状态
Liquid
缓冲液
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
As with all antibodies avoid freeze/thaw cycles.
储存条件
4 °C/-20 °C
储存方法
Store CBLC antibody at 4 °C or -20 °C.
抗原
CBLC
(Cbl proto-oncogene C (CBLC))
别名
CBLC
背景
Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.