CBLC 抗体 (AA 444 - 458)
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Quick Overview for CBLC 抗体 (AA 444 - 458) (ABIN2470158)
抗原
See all CBLC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 444 - 458
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- CBLC antibody was raised against amino acids 444 - 458 of CBLC (Human).
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应用备注
- CBLC antibody can be used in Western Blot, and immunohistochemistry starting at 10 μg/mL.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- As with all antibodies avoid freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store CBLC antibody at 4 °C or -20 °C.
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- CBLC (Cbl proto-oncogene C (CBLC))
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别名
- CBLC
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背景
- Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known.
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基因ID
- 23624
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UniProt
- Q9ULV8
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途径
- EGFR Signaling Pathway
抗原
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