HAVCR1 antibody can be used in immunohistochemistry starting at 5 μg/mL.
限制
仅限研究用
状态
Liquid
缓冲液
PBS, 0.05 % BSA, 0.05 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C/-20 °C
储存方法
Store HAVCR1 antibody at 4 °C for short term applications. For long term storage, aliquot and -20 °C.
抗原
HAVCR1
(Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
别名
HAVCR1
物质类
Virus
背景
HAVCR1, a 359 A.A Class 1 integral membrane glycoprotein, is used by Hepatitis A virus to infect humans. It consists of a conserved N-terminal Cys-rich region, IgV (Immunoglobulin Variable region like) domain and a TSP-rich mucin domain in the extracellular region followed by a highly conserved tyrosine kinase phosphorylation motif in the cytoplasmic region. HAVCR1 is expressed on terminally differentiated CD4+ Th2 cells and regulates cytokine production. It plays an important role in the regulation of immune responses in the development of asthma and allergic responses. Its expression is critically upregulated in dedifferentiated kidney cells, thus indicating a possible role in regeneration of proximal tubule epithelium in Kidneys. HAVCR1 has shown to be upregulated in renal carcinomas, suggesting its role in tumor progression and metastasis.