ALAS1 抗体 (AA 480-530)
Quick Overview for ALAS1 抗体 (AA 480-530) (ABIN2470088)
抗原
See all ALAS1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 480-530
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纯化方法
- Protein G Column
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免疫原
- ALAS1 antibody was raised against amino acids 480 - 530 of ALAS1 (Human).
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亚型
- IgG
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anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) (AA 1-98) antibody
ALAS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G10 unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) antibodyALAS1 适用: 人, 小鼠 WB, IF (cc) 宿主: 兔 Monoclonal 1G11 unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) (AA 57-285) antibodyALAS1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) (Internal Region) antibodyALAS1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) antibodyALAS1 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 2A9 unconjugated Recombinant Antibody
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) (AA 146-195) antibodyALAS1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) antibodyALAS1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) (AA 1-250) antibodyALAS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) (N-Term) antibodyALAS1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Aminolevulinate, delta-, Synthase 1 (ALAS1) antibodyALAS1 适用: 人 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- ALAS1 antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, 0.2 % gelatin, 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store ALAS1 antibody at 4 °C for short term applications. For long term storage, aliquot and -20 °C.
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- ALAS1 (Aminolevulinate, delta-, Synthase 1 (ALAS1))
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别名
- ALAS1
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背景
- ALAS-1 (EC 2.3.1.37) is a nuclear-encoded mitochondrial matrix enzymecatalyzing the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5 phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.
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基因ID
- 211
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UniProt
- P13196
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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