ITGA4 抗体 (C-Term)
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Quick Overview for ITGA4 抗体 (C-Term) (ABIN2469523)
抗原
See all ITGA4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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纯化方法
- Immunoaffinity Chromatography
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免疫原
- Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).
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应用备注
- Integrin alpha 4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, 0.1 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- As with all antibodies avoid freeze/thaw cycles.
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储存条件
- 4 °C/-80 °C
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储存方法
- Integrin alpha 4 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.
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- ITGA4 (Integrin alpha 4 (ITGA4))
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别名
- Integrin alpha 4
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背景
- ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.
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基因ID
- 3676
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UniProt
- P13612
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途径
- Integrin Complex
抗原
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