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ITGA4 抗体 (C-Term)

This 兔 多克隆 antibody specifically detects ITGA4 in IHC. It exhibits reactivity toward 人, 小鼠, 大鼠, 猴, 犬, Pig, 兔, Bat, Hamster, Gibbon 和 Gorilla.
产品编号 ABIN2469523
发货至: 中国
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Quick Overview for ITGA4 抗体 (C-Term) (ABIN2469523)

抗原

See all ITGA4 抗体
ITGA4 (Integrin alpha 4 (ITGA4))

适用

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人, 小鼠, 大鼠, 猴, 犬, Pig, 兔, Bat, Hamster, Gibbon, Gorilla

宿主

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克隆类型

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多克隆

标记

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This ITGA4 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 抗原表位

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    C-Term

    特异性

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.

    纯化方法

    Immunoaffinity Chromatography

    免疫原

    Integrin alpha 4 antibody was raised against a peptide located in the C-Terminal domain of Integrin alpha 4 (Human).
  • 应用备注

    Integrin alpha 4 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 μg/mL.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS, 0.1 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    As with all antibodies avoid freeze/thaw cycles.

    储存条件

    4 °C/-80 °C

    储存方法

    Integrin alpha 4 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.
  • 抗原

    ITGA4 (Integrin alpha 4 (ITGA4))

    别名

    Integrin alpha 4

    背景

    ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.

    基因ID

    3676

    UniProt

    P13612

    途径

    Integrin Complex
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