LDL-R antibody can be used for the detection of LDL-R by Western blot, may also work for IHC and ICC.
限制
仅限研究用
状态
Liquid
浓度
1 mg/mL
缓冲液
Phosphate-Buffered Saline. No preservatives added.
储存液
Without preservative
注意事项
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
储存条件
4 °C/-20 °C
储存方法
LDLR antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.
抗原
LDLR
(Low Density Lipoprotein Receptor (LDLR))
别名
LDLR
背景
Low density lipoprotein receptor. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.