Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
缓冲液
PBS
注意事项
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
储存条件
4 °C
储存方法
Thymidine Kinase monoclonal antibody can be stored at 4 °C, stable for one year.
抗原
TK1
(Thymidine Kinase 1, Soluble (TK1))
别名
Thymidine Kinase
背景
Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.