Huntingtin 抗体 (N-Term)
Quick Overview for Huntingtin 抗体 (N-Term) (ABIN2464133)
抗原
See all Huntingtin (HTT) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- Affinity Purified
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免疫原
- A synthetic peptide corresponding to the N-terminus.
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亚型
- IgG
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应用备注
- ELISA, Western (immuno) blotting, Immunostaining (in testing)
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限制
- 仅限研究用
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- Huntingtin (HTT)
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别名
- Huntington Protein
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背景
- Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington s disease protein is ~350 kDa in size and is localized in the brain.
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基因ID
- 3064
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UniProt
- P42858
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途径
- PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport
抗原
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