PIAS2 抗体
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北京 101111
Quick Overview for PIAS2 抗体 (ABIN2463619)
抗原
See all PIAS2 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antibody is purified by peptide affinity chromatography method.
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免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PIAS2.
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anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 385-473) antibody
PIAS2 适用: 人 WB, ELISA, IF, PLA, RNAi 宿主: 小鼠 Monoclonal 1F7 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) antibodyPIAS2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 人, 小鼠, 犬, Cow, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 109-140), (N-Term) antibodyPIAS2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB0678 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) antibodyPIAS2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 适用: 人, 小鼠, 犬, Cow, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 483-572) antibodyPIAS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- PIAS2 antibody can be used for detection of PIAS2 by ELISA at 1:1562500. PIAS2 antibody can be used for detection of PIAS2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
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注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store PIAS2 antibody at -20 °C.
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- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
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别名
- PIAS2
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背景
- Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.
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分子量
- 63 kDa
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基因ID
- 9063
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NCBI登录号
- NP_775298
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途径
- JAK/STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
抗原
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