Erythrocyte Ankyrin 抗体
Quick Overview for Erythrocyte Ankyrin 抗体 (ABIN2462605)
抗原
See all Erythrocyte Ankyrin (ANK1) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antibody is purified by protein A chromatography method.
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免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ANK1.
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anti-Ankyrin 1, Erythrocytic (ANK1) (C-Term) antibody
ANK1 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 豚鼠, Cow, 猴, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibodyANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 unconjugated
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (HRP)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 HRP
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (FITC)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 FITC
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (Biotin)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 Biotin
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (PE)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 PE
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (APC)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 APC
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (PerCP)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 PerCP
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (Atto 488)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 Atto 488
anti-Ankyrin 1, Erythrocytic (ANK1) (AA 1-1881) antibody (Atto 594)ANK1 适用: 人 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S388A-10 Atto 594
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应用备注
- ANK1 antibody can be used for detection of ANK1 by ELISA at 1:312500. ANK1 antibody can be used for detection of ANK1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
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注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store ANK1 antibody at -20 °C.
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- Erythrocyte Ankyrin (ANK1) (Ankyrin 1, Erythrocytic (ANK1))
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别名
- ANK1
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背景
- Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known.Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats, a central region with a highly conserved spectrin binding domain, and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known. Alternative polyadenylation accounting for the different sized erythrocytic ankyrin 1 mRNAs, has also been reported. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
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分子量
- 17 kDa, 206 kDa, 15 kDa, 8 kDa
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基因ID
- 286
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NCBI登录号
- NP_065211
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UniProt
- Q53ER1
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途径
- Synaptic Membrane
抗原
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