SRSF1 抗体
Quick Overview for SRSF1 抗体 (ABIN2462230)
抗原
See all SRSF1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Antibody is purified by peptide affinity chromatography method.
-
免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SFRS1.
-
-
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (pSer1) antibody
SRSF1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (N-Term) antibodySRSF1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (AA 6-33), (N-Term) antibodySRSF1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (AA 158-186), (C-Term) antibodySRSF1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20788 unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (C-Term) antibodySRSF1 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, 豚鼠, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (AA 16-224) antibodySRSF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (N-Term) antibodySRSF1 适用: 人, 小鼠, 大鼠 WB, IHC, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) antibodySRSF1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) (AA 11-38), (N-Term) antibodySRSF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22955 unconjugated
anti-serine/arginine-Rich Splicing Factor 1 (SRSF1) antibodySRSF1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- SFRS1 antibody can be used for detection of SFRS1 by ELISA at 1:62500. SFRS1 antibody can be used for detection of SFRS1 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
-
注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store SFRS1 antibody at -20 °C.
-
-
- SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))
-
别名
- SFRS1
-
背景
- SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].
-
分子量
- 27 kDa
-
基因ID
- 6426
-
NCBI登录号
- NP_008855
-
UniProt
- Q07955
-
途径
- Ribonucleoprotein Complex Subunit Organization
抗原
-
