SMAD1 抗体
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北京 101111
Quick Overview for SMAD1 抗体 (ABIN2461768)
抗原
See all SMAD1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antibody is purified by protein A chromatography method.
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免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SMAD1.
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anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 20-240) antibody
SMAD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-465) antibodySMAD1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-465) antibodySMAD1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2A1 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-110) antibodySMAD1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D3 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 202-335) antibodySMAD1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (pSer187) antibodySMAD1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 163-196) antibodySMAD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 20-330) antibodySMAD1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1356CT119-18-55 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 163-196) antibodySMAD1 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB43846 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (pSer465) antibodySMAD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- SMAD1 antibody can be used for detection of SMAD1 by ELISA at 1:1562500. SMAD1 antibody can be used for detection of SMAD1 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
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注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store SMAD1 antibody at -20 °C.
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- SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
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别名
- SMAD1
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背景
- SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
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分子量
- 52 kDa, 52 kDa, 52 kDa, 52 kDa, 52 kDa, 49 kDa
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基因ID
- 4086
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NCBI登录号
- NP_005891
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UniProt
- Q99717
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途径
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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