JunB 抗体
Our Local Distributor
北京 101111
Quick Overview for JunB 抗体 (ABIN2461653)
抗原
See all JunB (JUNB) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Antibody is purified by protein A chromatography method.
-
免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human JUNB.
-
-
-
-
应用备注
- JUNB antibody can be used for detection of JUNB by ELISA at 1:1562500. JUNB antibody can be used for detection of JUNB by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
-
注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store JUNB antibody at -20 °C.
-
-
- JunB (JUNB) (Jun B Proto-Oncogene (JUNB))
-
别名
- JUNB
-
背景
- The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
-
分子量
- 36 kDa
-
基因ID
- 3726
-
NCBI登录号
- NP_002220
-
UniProt
- P17275
抗原
-