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E2F4 抗体

This anti-E2F4 antibody is a 兔 多克隆 antibody detecting E2F4 in ELISA 和 WB. Suitable for 人, 小鼠 和 犬.
产品编号 ABIN2460194
发货至: 中国

Quick Overview for E2F4 抗体 (ABIN2460194)

抗原

See all E2F4 抗体
E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

适用

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  • 4
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  • 4
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  • 1
人, 小鼠, 犬

宿主

  • 38
  • 5
  • 2

克隆类型

  • 37
  • 8
多克隆

标记

  • 39
  • 3
  • 2
  • 1
This E2F4 antibody is un-conjugated

应用范围

  • 34
  • 23
  • 18
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  • 3
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  • 1
  • 1
ELISA, Western Blotting (WB)
  • 纯化方法

    Antibody is purified by peptide affinity chromatography method.

    免疫原

    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human E2F4.
  • 应用备注

    E2F4 antibody can be used for detection of E2F4 by ELISA at 1:312500. E2F4 antibody can be used for detection of E2F4 by western blot at 2.0/mL.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

    浓度

    1 mg/mL

    缓冲液

    Antibody is lyophilized in PBS buffer with 2 % sucrose.

    注意事项

    As with any antibody avoid repeat freeze-thaw cycles.

    储存条件

    4 °C/-20 °C

    储存方法

    For short periods of storage (days) store at 4 °C. For longer periods of storage, store E2F4 antibody at -20 °C.
  • 抗原

    E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

    别名

    E2F4

    背景

    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins. It is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It also plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

    分子量

    44 kDa

    基因ID

    1874

    NCBI登录号

    NP_001941

    UniProt

    Q16254

    途径

    Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size
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