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- 抗原 See all VPREB1 抗体
- VPREB1 (Pre-B Lymphocyte 1 (VPREB1))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VPREB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Antibody is purified by peptide affinity chromatography method.
- 免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human VPREB1.
- Top Product
- Discover our top product VPREB1 Primary Antibody
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anti-Pre-B Lymphocyte 1 (VPREB1) (AA 20-145) antibody
VPREB1 适用: 人 WB, ELISA, IHC, ICC, FACS, Neut 宿主: 小鼠 Monoclonal 5F8F3 unconjugated
anti-Pre-B Lymphocyte 1 (VPREB1) (AA 33-135) antibodyVPREB1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pre-B Lymphocyte 1 (VPREB1) (AA 43-128) antibodyVPREB1 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pre-B Lymphocyte 1 (VPREB1) (AA 43-134) antibodyVPREB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pre-B Lymphocyte 1 (VPREB1) (AA 36-85) antibodyVPREB1 适用: 人, 大鼠, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Pre-B Lymphocyte 1 (VPREB1) (AA 20-138) antibodyVPREB1 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- VPREB1 antibody can be used for detection of VPREB1 by ELISA at 1:12500. VPREB1 antibody can be used for detection of VPREB1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- 注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store VPREB1 antibody at -20 °C.
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- 抗原
- VPREB1 (Pre-B Lymphocyte 1 (VPREB1))
- 别名
- VPREB1 (VPREB1 产品)
- 别名
- IGI antibody, IGVPB antibody, VPREB antibody, VpreB antibody, CD179a antibody, Vpreb-1 antibody, V-set pre-B cell surrogate light chain 1 antibody, immunoglobulin iota chain antibody, immunoglobulin iota chain-like antibody, pre-B lymphocyte 1 antibody, pre-B lymphocyte gene 1 antibody, VPREB1 antibody, LOC698810 antibody, LOC486411 antibody, Vpreb1 antibody
- 背景
- VPREB1 belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation.CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like structure, but lacks the last beta-strand (beta7) of a typical V domain. Instead, it has a carboxyl terminal end that shows no sequence homologies to any other proteins. CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure, which is called the surrogate light chain or pseudo light chain. In this complex, the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b. On the surface of early preB cells, CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell receptor (preBCR). Though no CD179a-related human disease or pathology has been reported yet, the deficiency of other components of preB cell receptor such as CD179b, Ig mu heavy chain and CD79a has been shown to result in severe impairment of B cell development and agammaglobulinemia in human. PreBCR transduces signals for: 1) cellular proliferation, differentiation from the proB cell to preB cell stage, 2) allelic exclusion at the Ig heavy chain gene locus, and 3) promotion of Ig light chain gene rearrangements. Thus, preBCR functions as a checkpoint in early B cell development to monitor the production of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to associate with Ig light chain. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
- 分子量
- 16 kDa
- 基因ID
- 7441
- NCBI登录号
- NP_009059
- UniProt
- P12018
- 途径
- Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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