NUP98 抗体 (FGxxN Motif, N-Term)
Quick Overview for NUP98 抗体 (FGxxN Motif, N-Term) (ABIN2452065)
抗原
See all NUP98 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- FGxxN Motif, N-Term
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交叉反应 (详细)
- Not tested in other species
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纯化方法
- Purified
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过滤
- Sterile filtered
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免疫原
- Synthetic peptides containing conserved N-terminal sequence, GLFG, of Nup98 protein of Tetrahymena thermophila.
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亚型
- IgG1 kappa
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应用备注
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1) Most suitable for Western blotting,(Human,S. cerevisiae,S. pombe,Tetrahymena.)
2) Immunofluorescence staining / Immunocytochemistry for S. cerevisiae,S. pombe and T. etrahymena.
Not suitable for IF in human -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol. Azide- and carrier protein-free.
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Upon arrival centrifuge briefly and store at -20 C.
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: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).
: "Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 15, Issue 7, pp. 661-9, (2010) (PubMed).
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: "Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans." in: Monoclonal antibodies in immunodiagnosis and immunotherapy, Vol. 32, Issue 2, pp. 81-90, (2013) (PubMed).
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- NUP98 (Nucleoporin 98kDa (NUP98))
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别名
- Nup98
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背景
- Nucleoporin 98 (Nup98) is a component of nuclear pore complex (NPC), which is a large protein assembly embedded in the nuclear envelope and highly conserved in eukaryotes. It is localized on both nuclear and cytoplasmic side of NPC. This protein contains glycine-leucine-phenylalanine-glycine (GLFG) amino acid repeats and plays a critical role in nuclear trafficking. Nup98 also plays a specific role in the RNA export. In addition, Nup98 plays roles in several important biological events such as gene expression, mitotic checkpoint, and pathogenesis Nup98 gene is fused to a variety of partner genes in human myeloid and T-cell malignancies via chromosomal translocation. In ciliates, a unicellular organism having two functionally distinct nuclei, GLFG-Nup98 is present in one of the nuclei and a distinct Nup98 ortholog is present in the other nucleus, and these different Nup98s participate in a nucleus-selective transport mechanism.
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UniProt
- P52948
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途径
- Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome
抗原
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