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HIV-1 Nef (full length) 抗体

适用: Human Immunodeficiency Virus (HIV) WB, ELISA, IP, DB 宿主: 豚鼠 Polyclonal unconjugated
产品编号 ABIN2452025
发货至: 中国
  • 抗原
    HIV-1 Nef
    抗原表位
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length
    适用
    Human Immunodeficiency Virus (HIV)
    宿主
    • 11
    • 1
    • 1
    豚鼠
    克隆类型
    • 11
    • 2
    多克隆
    标记
    • 12
    • 1
    非结合性
    应用范围
    • 13
    • 12
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunoprecipitation (IP), Dot Blot (DB)
    产品特性
    Whole Antiserum
    纯化方法
    Guinea Pig serum
    免疫原
    Purified full-size recombinant Nef of HIV-1 subtype B expressed in E. coli
  • 应用备注
    1. Western blot: 1/1,000~1/3,000
    2. Dot blot: 1/3000
    3. Immunoprecipitation (assay dependent)
    4. ELISA (assay dependent)
    Other applications have not been tested
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Upon receipt aliquot and store at -20 C
  • Arora, Fredericksen, Garcia: "Nef: agent of cell subversion." in: Microbes and infection / Institut Pasteur, Vol. 4, Issue 2, pp. 189-99, (2002) (PubMed).

    Fackler, Baur: "Live and let die: Nef functions beyond HIV replication." in: Immunity, Vol. 16, Issue 4, pp. 493-7, (2002) (PubMed).

  • 抗原
    HIV-1 Nef
    物质类
    Viral Protein
    背景
    HIV-1 Nef (27 kDa) is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The name derives from its negative factor thought at the beginning but presently it is remarked as the protein which bears a most distinctive biological characteristic of AIDS virus. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of cell surface receptor proteins such as CD4 and MH4 which are important for AIDS virus infection.
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