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HIV-1 Nef (full length) 抗体

There are 2+ publications for this product available. The 豚鼠 多克隆 anti-HIV-1 Nef antibody is suitable to detect HIV-1 Nef in samples from Human Immunodeficiency Virus (HIV). It has been validated for WB, ELISA, DB 和 IP.
产品编号 ABIN2452025
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HIV-1 Nef (full length) 抗体 (ABIN2452025)

抗原

HIV-1 Nef

适用

Human Immunodeficiency Virus (HIV)

宿主

  • 9
豚鼠

克隆类型

  • 9
多克隆

标记

  • 8
  • 1
非结合性

应用范围

  • 9
  • 8
  • 2
  • 2
  • 2
Western Blotting (WB), ELISA, Dot Blot (DB), Immunoprecipitation (IP)
  • 抗原表位

    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    full length

    产品特性

    Whole Antiserum

    纯化方法

    Guinea Pig serum

    免疫原

    Purified full-size recombinant Nef of HIV-1 subtype B expressed in E. coli
  • 应用备注

    1. Western blot: 1/1,000~1/3,000
    2. Dot blot: 1/3000
    3. Immunoprecipitation (assay dependent)
    4. ELISA (assay dependent)
    Other applications have not been tested

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Upon receipt aliquot and store at -20 C
  • Arora, Fredericksen, Garcia: "Nef: agent of cell subversion." in: Microbes and infection / Institut Pasteur, Vol. 4, Issue 2, pp. 189-99, (2002) (PubMed).

    Fackler, Baur: "Live and let die: Nef functions beyond HIV replication." in: Immunity, Vol. 16, Issue 4, pp. 493-7, (2002) (PubMed).

  • 抗原

    HIV-1 Nef

    物质类

    Viral Protein

    背景

    HIV-1 Nef (27 kDa) is one of the accessory proteins synthesized in the early stage of AIDS virus reproduction and is abundantly found in infected cells. The name derives from its negative factor thought at the beginning but presently it is remarked as the protein which bears a most distinctive biological characteristic of AIDS virus. The protein interacts directly with the signal transduction protein of the host T cell and works effectively on AIDS infection or on long term survival of the infected cells or induces apoptosis of non-infected cells. It is also involved in the endocytosis and degradation of cell surface receptor proteins such as CD4 and MH4 which are important for AIDS virus infection.
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