Fc epsilon RI/FCER1A 抗体 (AA 85-172) (FITC)
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Quick Overview for Fc epsilon RI/FCER1A 抗体 (AA 85-172) (FITC) (ABIN2451978)
抗原
See all Fc epsilon RI/FCER1A (FCER1A) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 85-172
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产品特性
- The IgG fraction was purified from serum free culture medium of mouse hybridoma (CRA2) by propriety chromatography under mild conditions.
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纯化方法
- Purified
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过滤
- Sterile filtered
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免疫原
- AA 85-172 of FcepsilonR1alpha
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亚型
- IgG1 kappa
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anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 1-257) antibody
FCER1A 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2C12-3B6 unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 42-103) antibodyFCER1A 适用: 人, 小鼠 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 1F2A9 unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 26-205) antibodyFCER1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) antibodyFCER1A 适用: 人 FACS, WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 9E1 unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (C-Term) antibodyFCER1A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 1-257) antibodyFCER1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 101-220) antibodyFCER1A 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 24-204) antibodyFCER1A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 177-189) antibodyVerified FCER1A 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 1-257) antibodyFCER1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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1) FACS
2) Immunohistochemistry and immunocytochemistry
3) Inhibition of binding of IgE with FcepsilonR1alpha.
Titration of IgE-bound fraction of the FcepsilonR1alpha using CRA1 and CRA2 antibodies -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS ( pH 7.4), 50 % glycerol
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储存液
- Azide free
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储存条件
- -20 °C
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: "Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions." in: Bioscience, biotechnology, and biochemistry, Vol. 64, Issue 9, pp. 1856-67, (2001) (PubMed).
: "Direct expression of the extracellular portion of human FcepsilonRIalpha chain as inclusion bodies in Escherichia coli." in: Bioscience, biotechnology, and biochemistry, Vol. 65, Issue 1, pp. 79-85, (2001) (PubMed).
: "Enhanced expression of the high-affinity receptor for IgE (Fc(epsilon)RI) associated with decreased numbers of Langerhans cells in the lesional epidermis of atopic dermatitis." in: Journal of dermatological science, Vol. 27, Issue 3, pp. 156-61, (2001) (PubMed).
: "Functional expression of the high affinity receptor for IgE (FcepsilonRI) in human platelets and its' intracellular expression in human megakaryocytes." in: Blood, Vol. 93, Issue 8, pp. 2543-51, (1999) (PubMed).
: "The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding." in: The Journal of biological chemistry, Vol. 265, Issue 36, pp. 22079-81, (1991) (PubMed).
: "A macrophage Fc gamma receptor and the mast cell receptor for IgE share an identical subunit." in: Nature, Vol. 341, Issue 6244, pp. 752-4, (1989) (PubMed).
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: "Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions." in: Bioscience, biotechnology, and biochemistry, Vol. 64, Issue 9, pp. 1856-67, (2001) (PubMed).
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- Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
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背景
- FcεR1alpha is subunit of the high affinity receptor for IgE to which IgE directly binds. FcεR1alpha is a tetrameric complex consisting of one alpha, one beta and two γ subunits. The latter two are required for signal transduction activity. The FcεR1 complex plays an important role in triggering allergic responses. The CRA2 (AER24) monoclonal antibody reacts with the FcεR1alpha subunit on a region that overlaps the region of the IgE binding site, thus it competes with IgE for the receptor binding. Since the CRA1 (AER37) monoclonal antibody reacts with the site different from the IgE binding site on FcεR1alpha, it does not compete with IgE for the receptor binding. Combining the two antibodies, one can quantitatively measure the amounts of the IgE-bound FcεR1alpha.
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UniProt
- P12319
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途径
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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