Fc epsilon RI/FCER1A 抗体 (AA 1-84) (Biotin)
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北京 101111
Quick Overview for Fc epsilon RI/FCER1A 抗体 (AA 1-84) (Biotin) (ABIN2451975)
抗原
See all Fc epsilon RI/FCER1A (FCER1A) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-84
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产品特性
- The IgG fraction was purified from serum free culture medium of mouse hybridoma (CRA1) by propriety chromatography under mild conditions.
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纯化方法
- Purified
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过滤
- Sterile filtered
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免疫原
- AA 1-84 of FcepsilonR1alpha
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亚型
- IgG2b kappa
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anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 1-257) antibody
FCER1A 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2C12-3B6 unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 42-103) antibodyFCER1A 适用: 人, 小鼠 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 1F2A9 unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 26-205) antibodyFCER1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) antibodyFCER1A 适用: 人 FACS, WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 9E1 unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (C-Term) antibodyFCER1A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 1-257) antibodyFCER1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 101-220) antibodyFCER1A 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 24-204) antibodyFCER1A 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 177-189) antibodyVerified FCER1A 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Fc Fragment of IgE Receptor Ia (FCER1A) (AA 1-257) antibodyFCER1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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1) Western blotting: ~ 1 g/mL
2) FACS
3) Immuno-histochemistry and immuno-cytochemistry
4) Titration of IgE-bound receptor in combination with CRA2 antibody -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.6 mg/mL
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缓冲液
- PBS ( pH 7.4), 50 % glycerol
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储存液
- Azide free
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储存条件
- -20 °C
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: "IgE- and FcepsilonRI-mediated migration of human basophils." in: International immunology, Vol. 17, Issue 9, pp. 1249-55, (2005) (PubMed).
: "Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions." in: Bioscience, biotechnology, and biochemistry, Vol. 64, Issue 9, pp. 1856-67, (2001) (PubMed).
: "Direct expression of the extracellular portion of human FcepsilonRIalpha chain as inclusion bodies in Escherichia coli." in: Bioscience, biotechnology, and biochemistry, Vol. 65, Issue 1, pp. 79-85, (2001) (PubMed).
: "IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 9, pp. 5455-65, (1999) (PubMed).
: "The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding." in: The Journal of biological chemistry, Vol. 265, Issue 36, pp. 22079-81, (1991) (PubMed).
: "A macrophage Fc gamma receptor and the mast cell receptor for IgE share an identical subunit." in: Nature, Vol. 341, Issue 6244, pp. 752-4, (1989) (PubMed).
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: "IgE- and FcepsilonRI-mediated migration of human basophils." in: International immunology, Vol. 17, Issue 9, pp. 1249-55, (2005) (PubMed).
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- Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
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背景
- FcεR1alpha is subunit of the high affinity receptor for IgE to which IgE directly binds. FcεR1 is a tetrameric complex consisting of one alpha, one beta and two γ subunits. The latter two are required for signal transduction activity. The FcεR1 complex plays an important role in triggering allergic responses. The CRA1 (AER37) monoclonal antibody reacts with the FcεR1alpha subunit on a region that does not overlap the region of the IgE binding site, thus it does not compete with IgE for the receptor binding. Since the CRA2 (AER24) monoclonal antibody reacts with the IgE binding site on FcεR1alpha, it competes with IgE for the receptor binding. Combining the two antibodies, one can quantitatively measure the amounts of the IgE-bound FcεR1alpha.
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UniProt
- P12319
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途径
- Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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